AestheFill Collagen Biostimulator
AestheFill® is a combination of “Aesthetic” and “Dermal Filler,” representing a highly aesthetic volumizing solution. Beyond adding volume, AestheFill® helps contour and refine facial features with a natural-looking result.
Distinctive microsphere structure
With its distinctive microsphere structure, AestheFill optimizes the stimulation of Type I collagen and elastin production, helping improve skin elasticity and overall skin quality while supporting a youthful, smooth, and firm appearance.
Key structural features
- Medical-grade PDLLA – recognized by the U.S. FDA for its safety and applicability in medical filling devices.
- Optimized microsphere size (40–53 μm) – uniform spherical particles allow even distribution within the tissue, helping minimize the risk of inflammatory and hypersensitivity reactions.
- High-density porous microsphere surface – facilitates fibroblast infiltration and supports collagen stimulation.
- Sponge-like internal structure – allows cells to migrate into the microspheres, promoting the regeneration of the skin’s natural structure.
Indications
As a PDLLA–CMC collagen biostimulator, AestheFill works by supporting the body’s natural collagen production, helping improve dermal structure and enhance overall skin quality over time.
Through this biological mechanism, AestheFill helps address several common signs of skin aging:
- Softens the appearance of wrinkles
- Improves the look of enlarged pores
- Supports the treatment of atrophic acne scars and depressed scars
Rather than acting only on the surface, AestheFill is designed to strengthen the skin foundation from within, delivering natural-looking, balanced, and long-lasting rejuvenation.
At the core of AestheFill is its porous PDLLA microsphere technology. Once introduced into the tissue, PDLLA activates macrophages, which in turn stimulate fibroblast proliferation and support the synthesis of type I/III collagen and elastin. This process gradually forms a new collagen network over time, helping improve firmness, elasticity, and overall skin quality in a more sustainable way.
Key benefits of AestheFill include:
- Initial volumizing support
- Progressive stimulation of endogenous collagen
- Natural and long-term structural tissue improvement
AestheFill is suitable for multiple treatment areas, including the temples, cheeks, nasolabial folds, marionette lines, sagging skin, neck, and the backs of the hands, especially in indications that benefit from a biostimulatory approach combined with volume support.
AestheFill is suitable for cases involving volume loss, reduced tissue elasticity, and age-related changes that require gradual improvement over time. The optimal treatment course typically consists of 1 to 3 sessions, spaced 4 to 6 weeks apart, depending on the degree of tissue deficiency, dilution protocol, and the treatment plan individualized by the physician.
AestheFill is a medical device intended for professional use and must be reconstituted and used in accordance with appropriate professional guidelines. Possible post-treatment reactions may include mild redness, bruising, hematoma, or small palpable nodules at the injection site.
AestheFill is supported by a strong quality and regulatory foundation within the category of injectable collagen stimulators. The manufacturer’s certification system includes ISO 13485, Korea Good Manufacturing Practice, AestheFill CE Design Examination, AestheFill CE Full Quality Assurance System, and AestheFill Vietnam Registration.