{"id":872,"date":"2026-04-15T06:26:57","date_gmt":"2026-04-15T06:26:57","guid":{"rendered":"https:\/\/grassroots.com.vn\/?p=872"},"modified":"2026-07-06T13:18:03","modified_gmt":"2026-07-06T08:18:03","slug":"aesthefill-pdlla-cmc-in-skin-rejuvenation","status":"publish","type":"post","link":"https:\/\/grassroots.com.vn\/en\/aesthefill-pdlla-cmc-in-skin-rejuvenation\/","title":{"rendered":"AestheFill PDLLA-CMC in Skin Rejuvenation: When Collagen Stimulation Must Go Hand in Hand with Clinical Safety"},"content":{"rendered":"<p><span data-contrast=\"auto\">In today\u2019s aesthetic medicine landscape, the demand for beauty enhancement no longer stops at instant surface-level improvement. Instead, both physicians and patients are increasingly prioritizing solutions that enhance skin quality from within, delivering natural, harmonious, and long-lasting results over time.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Against this backdrop, skin rejuvenation approaches based on stimulating the body\u2019s own collagen production are receiving growing attention. AestheFill PDLLA-CMC was also a key topic at a recent scientific symposium, where it was discussed from two essential perspectives: collagen stimulation efficacy and clinical safety in practice.<\/span><\/p>\n<p>&nbsp;<\/p>\n<figure id=\"attachment_874\" aria-describedby=\"caption-attachment-874\" style=\"width: 2560px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"size-full wp-image-874\" src=\"https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626708752910_82966dac7c861865bdbc485a1c0e1bb0.jpg\" alt=\"Aesthefill\" width=\"2560\" height=\"1796\" srcset=\"https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626708752910_82966dac7c861865bdbc485a1c0e1bb0.jpg 2560w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626708752910_82966dac7c861865bdbc485a1c0e1bb0-300x210.jpg 300w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626708752910_82966dac7c861865bdbc485a1c0e1bb0-1024x718.jpg 1024w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626708752910_82966dac7c861865bdbc485a1c0e1bb0-768x539.jpg 768w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626708752910_82966dac7c861865bdbc485a1c0e1bb0-1536x1078.jpg 1536w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626708752910_82966dac7c861865bdbc485a1c0e1bb0-2048x1437.jpg 2048w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626708752910_82966dac7c861865bdbc485a1c0e1bb0-350x246.jpg 350w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626708752910_82966dac7c861865bdbc485a1c0e1bb0-600x421.jpg 600w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626708752910_82966dac7c861865bdbc485a1c0e1bb0-uai-720x505.jpg 720w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626708752910_82966dac7c861865bdbc485a1c0e1bb0-uai-900x631.jpg 900w\" sizes=\"(max-width: 2560px) 100vw, 2560px\" \/><figcaption id=\"caption-attachment-874\" class=\"wp-caption-text\">Overview of the scientific symposium on the application of PDLLA-CMC in skin rejuvenation, attracting strong interest from physicians and professional attendees.<\/figcaption><\/figure>\n<p><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h2 style=\"text-align: center;\">The trend in skin rejuvenation is moving toward natural and sustainable outcomes<\/h2>\n<p><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">If many people once turned to aesthetics with the expectation of rapid transformation, today the criteria have evolved. A beautiful result is no longer defined solely by a fuller face or softened wrinkles, but also by overall skin quality, facial harmony, and a natural post-treatment appearance.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">This shift has raised the standards for selecting both materials and techniques\u00a0in\u00a0skin rejuvenation.\u00a0An appropriate solution\u00a0must not only help improve signs of aging, but also support natural regeneration, minimize the look of overt intervention, and ensure safety in clinical practice. That was also the guiding theme of the symposium on PDLLA-CMC in skin rejuvenation.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<figure id=\"attachment_873\" aria-describedby=\"caption-attachment-873\" style=\"width: 2560px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"size-full wp-image-873\" src=\"https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626708752986_4ff59451476d93e8a8ff1aeae907f7e3.jpg\" alt=\"Aesthefill\" width=\"2560\" height=\"1730\" srcset=\"https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626708752986_4ff59451476d93e8a8ff1aeae907f7e3.jpg 2560w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626708752986_4ff59451476d93e8a8ff1aeae907f7e3-300x203.jpg 300w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626708752986_4ff59451476d93e8a8ff1aeae907f7e3-1024x692.jpg 1024w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626708752986_4ff59451476d93e8a8ff1aeae907f7e3-768x519.jpg 768w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626708752986_4ff59451476d93e8a8ff1aeae907f7e3-1536x1038.jpg 1536w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626708752986_4ff59451476d93e8a8ff1aeae907f7e3-2048x1384.jpg 2048w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626708752986_4ff59451476d93e8a8ff1aeae907f7e3-350x237.jpg 350w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626708752986_4ff59451476d93e8a8ff1aeae907f7e3-600x405.jpg 600w\" sizes=\"(max-width: 2560px) 100vw, 2560px\" \/><figcaption id=\"caption-attachment-873\" class=\"wp-caption-text\">Scientific symposium on the application of PDLLA-CMC in skin rejuvenation, co-organized by the University Medical Center Ho Chi Minh City and Grassroots.<\/figcaption><\/figure>\n<p><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h2 style=\"text-align: center;\">AestheFill PDLLA-CMC and its mechanism in supporting natural collagen stimulation<\/h2>\n<p><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">The symposium was chaired by Assoc. Prof. Dr. Le Thai Van Thanh, with presentations by Dr. Camelo Crisafulli (Italy), Dr. Pham Cam Thuy, Dr. Ta Quoc Hung, and Dr. Thach Van Toan.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">One of the key topics of interest was how AestheFill PDLLA-CMC is viewed as a skin rejuvenation solution based on stimulation. Rather than focusing only on immediate visible improvement, this approach emphasizes the body\u2019s own regenerative capacity, especially its ability to support endogenous collagen production.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">In his presentation, Dr. Camelo Crisafulli focused on the application of PDLLA-CMC in improving signs of aging. This perspective helps explain why collagen-stimulating solutions are becoming increasingly important: they align with the growing demand for natural-looking rejuvenation, create less sense of obvious intervention, and aim to improve skin quality progressively over time.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<figure id=\"attachment_854\" aria-describedby=\"caption-attachment-854\" style=\"width: 2560px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"size-full wp-image-854\" src=\"https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626714014608_ab5de2d0f3f355bc209786d6d74034ba.jpg\" alt=\"Aesthefill\" width=\"2560\" height=\"1627\" srcset=\"https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626714014608_ab5de2d0f3f355bc209786d6d74034ba.jpg 2560w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626714014608_ab5de2d0f3f355bc209786d6d74034ba-300x191.jpg 300w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626714014608_ab5de2d0f3f355bc209786d6d74034ba-1024x651.jpg 1024w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626714014608_ab5de2d0f3f355bc209786d6d74034ba-768x488.jpg 768w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626714014608_ab5de2d0f3f355bc209786d6d74034ba-1536x976.jpg 1536w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626714014608_ab5de2d0f3f355bc209786d6d74034ba-2048x1302.jpg 2048w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626714014608_ab5de2d0f3f355bc209786d6d74034ba-350x222.jpg 350w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626714014608_ab5de2d0f3f355bc209786d6d74034ba-600x381.jpg 600w\" sizes=\"(max-width: 2560px) 100vw, 2560px\" \/><figcaption id=\"caption-attachment-854\" class=\"wp-caption-text\">Representatives of the organizing committee and speakers at the workshop on the application of PDLLA-CMC in skin rejuvenation.<\/figcaption><\/figure>\n<h2 style=\"text-align: center;\">Clinical data from Vietnam helps clarify real-world applicability<\/h2>\n<p><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Beyond\u00a0mechanism\u00a0of action, real-world applicability is a critical factor when evaluating any skin rejuvenation solution. At the symposium, Dr. Pham Cam Thuy presented on clinical response following PDLLA-CMC treatment in Vietnam.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">What stands out is that these data provide a perspective rooted in local practice. In aesthetic medicine, a solution may be highly regarded from an academic standpoint, but\u00a0its\u00a0true clinical value becomes clearer only when assessed in real treatment settings. Clinical experience from Vietnam therefore helps bridge theoretical foundations with practical needs, giving physicians\u00a0additional\u00a0support when choosing the most\u00a0appropriate treatment\u00a0approach.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h2 style=\"text-align: center;\">Clinical safety is not optional. It is essential alongside collagen stimulation efficacy<\/h2>\n<p><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">A major highlight of the program was that clinical safety was not treated as a secondary consideration, but as a central theme throughout the symposium. This reflects an important reality in modern skin rejuvenation: treatment outcomes cannot be separated from the ability to control risk across the entire procedure.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">In his presentation, Dr. Ta Quoc Hung addressed safety strategies and complication management when using PDLLA-CMC. This reinforced the idea that the value of a solution lies not only in its\u00a0collagen-stimulating mechanism, but also in how well indications, techniques, and the management of clinical situations are standardized.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<figure id=\"attachment_855\" aria-describedby=\"caption-attachment-855\" style=\"width: 2048px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"size-full wp-image-855\" src=\"https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626714014606_9e0efd201413e437cf6b8cef7f6bce99.jpg\" alt=\"Asthefill\" width=\"2048\" height=\"1365\" srcset=\"https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626714014606_9e0efd201413e437cf6b8cef7f6bce99.jpg 2048w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626714014606_9e0efd201413e437cf6b8cef7f6bce99-300x200.jpg 300w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626714014606_9e0efd201413e437cf6b8cef7f6bce99-1024x683.jpg 1024w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626714014606_9e0efd201413e437cf6b8cef7f6bce99-768x512.jpg 768w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626714014606_9e0efd201413e437cf6b8cef7f6bce99-1536x1024.jpg 1536w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626714014606_9e0efd201413e437cf6b8cef7f6bce99-350x233.jpg 350w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626714014606_9e0efd201413e437cf6b8cef7f6bce99-600x400.jpg 600w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/z7626714014606_9e0efd201413e437cf6b8cef7f6bce99-uai-720x480.jpg 720w\" sizes=\"(max-width: 2048px) 100vw, 2048px\" \/><figcaption id=\"caption-attachment-855\" class=\"wp-caption-text\">Overview of the scientific workshop on the application of PDLLA-CMC in skin rejuvenation.<\/figcaption><\/figure>\n<h2 style=\"text-align: center;\">From theory to practice: a live demonstration of PDLLA-CMC application<\/h2>\n<p><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">In addition to the scientific presentations, the symposium also featured a live demonstration of PDLLA-CMC application for rejuvenation of the face, neck, and hands, performed by Dr. Thach Van Toan. This session helped attendees better visualize how the technique is implemented in real clinical practice.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">The combination of academic discussion and live\u00a0demonstration\u00a0created clear value. While the theoretical sessions clarified mechanism, indications, and safety principles, the live demo showed how the technique can be translated into actual treatment.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h2 style=\"text-align: center;\">AestheFill PDLLA-CMC aligns with today\u2019s skin rejuvenation trends<\/h2>\n<p><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">The product highlighted throughout the symposium was AestheFill, a PDLLA-CMC solution developed by Regen Biotech (Korea). According to the symposium content, this is a PDLLA-based collagen stimulator approved by the KFDA and specifically designed to improve wrinkles through collagen stimulation.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">As patients increasingly\u00a0seek\u00a0natural, sustainable beauty results with minimal signs of overcorrection, AestheFill PDLLA-CMC appears well aligned with current treatment trends. In Vietnam, AestheFill is distributed by Grassroots JSC, further reinforcing its presence in the skin rejuvenation segment with a focus on safety and long-term outcomes.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<figure id=\"attachment_875\" aria-describedby=\"caption-attachment-875\" style=\"width: 2048px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"size-full wp-image-875\" src=\"https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/DSC_6678.jpg\" alt=\"Aesthefill\" width=\"2048\" height=\"1365\" srcset=\"https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/DSC_6678.jpg 2048w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/DSC_6678-300x200.jpg 300w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/DSC_6678-1024x683.jpg 1024w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/DSC_6678-768x512.jpg 768w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/DSC_6678-1536x1024.jpg 1536w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/DSC_6678-350x233.jpg 350w, https:\/\/grassroots.com.vn\/wp-content\/uploads\/2026\/04\/DSC_6678-600x400.jpg 600w\" sizes=\"(max-width: 2048px) 100vw, 2048px\" \/><figcaption id=\"caption-attachment-875\" class=\"wp-caption-text\">AestheFill brand presence at the event, contributing to both the professional atmosphere and the overall symposium experience.<\/figcaption><\/figure>\n<h2 style=\"text-align: center;\">Conclusion<\/h2>\n<p><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Today\u2019s skin rejuvenation trends are shifting strongly toward solutions that respect the body\u2019s natural mechanisms, with endogenous collagen stimulation becoming increasingly valued. However, stimulation alone is not enough.\u00a0Its\u00a0true value lies in being paired with clinical safety and real-world applicability.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">From the content presented at the symposium, AestheFill PDLLA-CMC stands out as a solution well suited to modern aesthetic thinking: improving underlying skin quality, preserving natural beauty, and placing safety at the center of treatment.<\/span><\/p>\n<hr \/>\n<blockquote><p>AestheFill \u2013 A Natural, Science-Driven, and Sustainable Rejuvenation Solution<br \/>\n<a href=\"https:\/\/www.facebook.com\/aesthefillvn\" target=\"_blank\" rel=\"noopener\">Explore more about LDLLA-CMC technology and the science of collagen-based rejuvenation<\/a><\/p><\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>In today\u2019s aesthetic medicine landscape, the demand for beauty enhancement no longer stops at instant surface-level improvement. Instead, both physicians [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":874,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"rs_blank_template":"","rs_page_bg_color":"","slide_template_v7":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-872","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.9) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>AestheFill PDLLA-CMC in Skin Rejuvenation: When Collagen Stimulation Must Go Hand in Hand with Clinical Safety | Grassroots<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/grassroots.com.vn\/en\/aesthefill-pdlla-cmc-in-skin-rejuvenation\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"AestheFill PDLLA-CMC in Skin Rejuvenation: When Collagen Stimulation Must Go Hand in Hand with Clinical Safety\" \/>\n<meta property=\"og:description\" content=\"In today\u2019s aesthetic medicine landscape, the demand for beauty enhancement no longer stops at instant surface-level improvement. 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